Pyrrolo[2,1- d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

Pyrrolo[2,1- d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) Vol. 55; no. 3; pp. 200 - 201
Main Authors: Diana, P., Barraja, P., Lauria, A., Almerico, A.M., Dattolo, G., Cirrincione, G.
Format: Journal Article
Language:English
Published: France Elsevier SAS 01-03-2000
Subjects:
Antineoplastic agents
Antineoplastic Agents, Alkylating - chemical synthesis
Antineoplastic Agents, Alkylating - pharmacology
Azolotetrazines
Dacarbazine - analogs & derivatives
Dacarbazine - chemical synthesis
Dacarbazine - pharmacology
Heterocyclic Compounds, 2-Ring - chemical synthesis
Heterocyclic Compounds, 2-Ring - pharmacology
Pyrrolotetrazines
Temozolomide
Azolotetrazines
Pyrrolotetrazines
Temozolomide
Antineoplastic agents
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Summary:The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(00)00022-7