Tomato juice inhibits adenosine deaminase activity in human prostate tissue from patient with prostate cancer

• Published in: Nutrition research (New York, N.Y.) Vol. 23; no. 9; pp. 1183 - 1188
• Main Authors: Durak, İlker, Biri, Hasan, Avcı, Aslıhan, Sözen, Sinan, Devrim, Erdinç
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-09-2003; Elsevier Science
• Subjects: Adenosine deaminase; Biological and medical sciences; humans; Medical sciences; Nephrology. Urinary tract diseases; patients; Prostate cancer; prostatic neoplasms; protective effect; tissues; Tomato; tomato juice; tomatoes; Tumors of the urinary system; Urinary tract. Prostate gland; Tomato; Prostate cancer; Adenosine deaminase; Human; Urinary system disease; Prostate disease; Enzyme; Vegetable juice; Male; Supplemented diet; Malignant tumor; Feeding; Prevention; Enzymatic activity; Hydrolases; Male genital diseases; Urogenital system; Prostate
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(03)00115-5

Investigation of possible effects of tomato juice on adenosine deaminase (ADA) activity in prostate tissue from cancer patients was aimed in this study. Ten prostate tissues from patients with pathologically proven localised prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of tomato juice were performed. Tomato juice causes significant inhibition on ADA activity in the prostate tissues. Protective effect proposed for tomato against prostate cancer may result from its inhibition potential on ADA.