Effect of aminophylline on brain blood flow in the newborn piglet

The effect of 6 mg/kg of aminophylline on brain blood flow was examined in newborn piglets. Arterial plasma aminophylline concentration averaged 7 mg/l. Total brain, regional brain (cerebrum, cerebellum and stem) and eye blood flow as well as the total brain oxygen consumption were not altered by am...

Full description

Saved in:

Bibliographic Details
Published in:	Developmental pharmacology and therapeutics Vol. 6; no. 4; p. 248
Main Authors:	Stonestreet, B S, Nowicki, P T, Hansen, N B, Petit, R, Oh, W
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-1983
Subjects:	Aminophylline - pharmacology Animals Animals, Newborn - physiology Blood Gas Analysis Blood Pressure - drug effects Carbon Dioxide - metabolism Cerebrovascular Circulation - drug effects Heart Rate - drug effects Hematocrit Oxygen Consumption - drug effects Swine
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of 6 mg/kg of aminophylline on brain blood flow was examined in newborn piglets. Arterial plasma aminophylline concentration averaged 7 mg/l. Total brain, regional brain (cerebrum, cerebellum and stem) and eye blood flow as well as the total brain oxygen consumption were not altered by aminophylline treatment. Choroid plexus blood flow was five times higher than the total brain blood flow in these newborn piglets. In contrast to brain blood flow, choroid plexus blood flow decreased significantly following aminophylline administration.
ISSN:	0379-8305
DOI:	10.1159/000457311