Effect of Ibuprofen on Gross Pathology, Bacterial Count, and Levels of Prostaglandin E2 in Experimental Staphylococcal Osteomyelitis

• Published in: The Journal of infectious diseases Vol. 154; no. 4; pp. 627 - 630
• Main Authors: Rissing, J. Peter, Buxton, Thomas B.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-10-1986; University of Chicago Press
• Subjects: Animals; Biological and medical sciences; Bone and Bones - pathology; Bones, joints and connective tissue. Antiinflammatory agents; Dinoprostone; Ibuprofen - pharmacology; Ibuprofen - therapeutic use; Male; Medical sciences; Osteomyelitis - drug therapy; Osteomyelitis - metabolism; Osteomyelitis - microbiology; Osteomyelitis - pathology; Pharmacology. Drug treatments; Prostaglandins E - metabolism; Rats; Rats, Inbred Strains; Staphylococcal Infections - drug therapy; Staphylococcal Infections - metabolism; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Staphylococcus aureus - drug effects; Tibia; Rat; Rodentia; Diseases of the osteoarticular system; Prostaglandin E2; Bacteriological investigation; Infection; Non steroidal antiinflammatory agent; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Animal; Osteitis; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Staphylococcal infection; Staphylococcus aureus
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/154.4.627

Infections with Staphylococcus aureus were induced in rat tibiae without sclerosing agents. Animals received ibuprofen or 0.9% NaCI. Both ibuprofen-treated and control animals developed a progressively more-destructive disease over 12 days. Gross tibial pathology was significantly reduced in animals receiving ibuprofen for both six and 12 days postinfection. Radiographic evidence of osteomyelitis was attenuated at 12days. Geometric mean counts of S. aureus were, however, not significantly changed by ibuprofen treatment. Mean levels of prostaglandin E2 (PGE2) were highest in untreated controls. Ibuprofen treatment of infected animals was associated with a much-reduced mean value of PGE2. Ibuprofen-treated infected tibiae disclosed less PGE2 than did either ibuprofen- or NaCI-treated uninfected tibiae.