Mobilisation strategies for normal and malignant cells

• Published in: Pathology Vol. 43; no. 6; pp. 547 - 565
• Main Authors: To, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E.J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C., Lewis, Ian D.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-10-2011
• Subjects: Animals; Haemopoietic stem cells; Hematopoietic Stem Cell Mobilization - methods; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - cytology; Humans; immune cells; leukaemic cells; Mesenchymal Stromal Cells - cytology; mobilisation; Models, Animal; Transplantation Conditioning - methods; AML; ALL; CLL; OS; HGF; immune cells; GVHD; G-CSF; Haemopoietic stem cells; GM-CSF; SCF; ALC; MGDF; HSCs; mobilisation; PFS; leukaemic cells
• ISSN: 0031-3025; 1465-3931
• DOI: 10.1097/PAT.0b013e32834a9eb8

This review evaluates the latest information on the mobilisation of haemopoietic stem cells for transplantation, with the focus on what is the current best practice and how new understanding of the bone marrow stem cell niche provides new insights into optimising mobilisation regimens. The review then looks at the mobilisation of mesenchymal stromal cells, immune cells as well as malignant cells and what clinical implications there are.