Resveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model

• Published in: Biochemical and biophysical research communications Vol. 254; no. 3; pp. 739 - 743
• Main Authors: Carbó, Neus, Costelli, Paola, Baccino, Francesco M., López-Soriano, Francisco J., Argilés, Josep M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27-01-1999
• Subjects: AGENTES ANTINEOPLASTICOS; Animals; ANTINEOPLASTIC AGENTS; Antineoplastic Agents, Phytogenic - pharmacology; apoptosis; cancer; Cell Cycle - drug effects; Cell Division - drug effects; chemotherapeutic potential; CRECIMIENTO; CROISSANCE; Flow Cytometry; GROWTH; Liver Neoplasms, Experimental - pathology; MEDICAMENT CYTOSTATIQUE; NEOPLASMAS; NEOPLASME; NEOPLASMS; RAT; RATA; RATS; resveratrol; Stilbenes - pharmacology; VIN; VINOS; wine; Wine - analysis; WINES; chemotherapeutic potential; apoptosis; cancer; resveratrol; wine
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1006/bbrc.1998.9916

Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G2/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number.