Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs - a review
Quinoline, which consists of benzene fused with N -heterocyclic pyridine, has received considerable attention as a core template in drug design because of its broad spectrum of bioactivity. This review aims to present the recent advances in chemistry, medicinal potential and pharmacological applicat...
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| Published in: | RSC advances Vol. 12; no. 29; pp. 18594 - 18614 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cambridge
Royal Society of Chemistry
24-06-2022
The Royal Society of Chemistry |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Quinoline, which consists of benzene fused with
N
-heterocyclic pyridine, has received considerable attention as a core template in drug design because of its broad spectrum of bioactivity. This review aims to present the recent advances in chemistry, medicinal potential and pharmacological applications of quinoline motifs to unveil their substantial efficacies for future drug development. Essential information in all the current and available literature used was accessed and retrieved using different search engines and databases, including Scopus, ISI Web of Knowledge, Google and PUBMED. Numerous derivatives of the bioactive quinolines have been harnessed
via
expeditious synthetic approaches, as highlighted herein. This review reveals that quinoline is an indisputable pharmacophore due to its tremendous benefits in medicinal chemistry research and other valuable areas of human endeavour. The recent
in vivo
and
in vitro
screening reported by scientists is highlighted herein, which may pave the way for novel drug development. Owing to the array of information available and highlighted herein on the medicinal potential of quinoline and its functionalized derivatives, a new window of opportunity may be opened to medicinal chemists to access more biomolecular quinolines for future drug development.
Quinoline, which consists of benzene fused with
N
-heterocyclic pyridine, has received considerable attention as a core template in drug design because of its broad spectrum of bioactivity. |
|---|---|
| Bibliography: | Olayinka Oyewale AJANI was born in Ile-ife and attained his elementary and secondary school education in Ibadan. He obtained his Bachelor's and Master's Degree in Chemistry from Obafemi Awolowo University, Ile-ife, Osun State, Nigeria. He joined Covenant University Ota Ogun State, Nigeria in 2005, where he obtained his Doctoral Degree in Chemistry in 2012. Olayinka Ajani is a Professor of Chemistry who has established himself both as an academic and a researcher in the areas of organic synthesis and medicinal chemistry. He is a recipient of many prestigious awards and grants including the German DAAD Research Visit Award and The Royal Society of Chemistry Grant. He had his Postdoctoral Fellowship at Philipps University, Marburg, Germany under the research group of Professor Martin Schlitzer. Currently, Prof. Ajani is the Director of Covenant University Central Instrumentation Research Facility (CUCIRF). He is a member of notable professional bodies such as The Royal Society of Chemistry (RSC) and Chemical Society of Nigeria (CSN). He is happily married and blessed with children. King Tamunodikibugerere IYAYE was born in Okrika and attained his elementary and secondary school education in Rivers State. He obtained his Bachelor's and Master's Degree in Industrial Chemistry from Covenant University, Ota, Ogun State. His BSc dissertation was entitled Synthesis, Characterization and Antibacterial Activity of Novel Hydrazide-Hydrazones of Quinoline. King is a first-class student who finished his BSc with a CGPA of 4.87 out of 5.00, which earned him a scholarship with Covenant University, Ota Ogun State with his research focused on functional and biologically active oxadiazole linked to quinoxaline. His carried out his project under the supervision of Prof. O. O. Ajani. King's Master's thesis was titled Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-Linked 1,4-Dihydroquinoxaline Derivatives. He completed his Master's Degree with a CGPA of 5.0/5.0. Furthermore, King has been actively involved in research leading to publications in accredited/peer-reviewed scientific journals. He has, to his credit, publications in reputable journals, which are indexed in the Scopus database. Mrs Olabisi Ademosun was born in Ota, Ogun State and attained her elementary and secondary school education in the same town, Ota. She obtained her Bachelor's Degree in Pure Chemistry from Olabisi Onabanjo University, Ago Iwoye, Ogun State, Nigeria and Master's Degree in Industrial Chemistry from Covenant University, Ota, Ogun-State, Nigeria, where she is currently a PhD student working on cancer nutrition. Mrs Ademosun has been actively involved in collaboration with other researchers, home and abroad, leading to publications in accredited/peer-reviewed scientific journals. Olabisi T. Ademosun is an Assistant Lecturer who is involved with teaching and projects and research supervision at the undergraduate level at Covenant University. She has served and still serving in various capacities in various committees at the Departmental, College and University levels. She is a member of The Royal Society of Chemistry (RSC). Mrs Ademosun is happily married and blessed with children to the glory of God. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/d2ra02896d |