Hepatotoxicity due to zinc phosphide poisoning in two patients: role of N‐acetylcysteine

• Published in: Clinical case reports Vol. 4; no. 8; pp. 768 - 772
• Main Authors: Oghabian, Zohreh, Afshar, Arefeh, Rahimi, Hamid Reza
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-08-2016; John Wiley and Sons Inc
• Subjects: Aluminum; Analgesics; Antioxidants; Case Report; Case Reports; Common signs; Cytochrome; Edema; Electrolytes; Enzymes; Free radicals; hepatotoxicity; Laboratories; Liver; Metabolism; N‐acetylcysteine; Patients; Phosphatase; Poisoning; rodenticide; successful management; Vital signs; Zinc; Common signs; rodenticide; hepatotoxicity; N‐acetylcysteine; successful management
• ISSN: 2050-0904; 2050-0904
• DOI: 10.1002/ccr3.618

Key Clinical Message
Zinc phosphide (Zn3P2/ZnP) is used as a rodenticide. The most common signs of toxicity are nausea, vomiting, hypotension, and metabolic acidosis; patients presenting such signs are referred to the emergency department (ED) of the hospitals. Therefore, this study aimed to report two cases of hepatotoxicity following accidental and intentional ZnP poisoning and successful management with N‐acetylcysteine (NAC).
Zinc phosphide (Zn3P2/ZnP) is used as a rodenticide. The most common signs of toxicity are nausea, vomiting, hypotension, and metabolic acidosis; patients presenting such signs are referred to the emergency department (ED) of the hospitals. Therefore, this study aimed to report two cases of hepatotoxicity following accidental and intentional ZnP poisoning and successful management with N‐acetylcysteine (NAC).