Multimodal Therapy in the Management of Advanced Penile Cancer

A multimodal approach to therapy is increasingly used in treating men with advanced penile cancer. Adjuvant chemotherapy improves outcomes in chemotherapy-naïve men with node-positive positive disease, and neoadjuvant chemotherapy can downstage bulky nodal disease sufficiently to permit surgery and...

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Bibliographic Details
Published in:	Urologic clinics of North America Vol. 43; no. 4; pp. 469 - 479
Main Authors:	Ravi, Praful, MBBChir, Pagliaro, Lance C., MD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2016
Subjects:	Adjuvant chemotherapy Combined Modality Therapy Disease Management Humans Male Neoadjuvant chemotherapy Neoplasm Staging Penile cancer Penile Neoplasms - diagnosis Penile Neoplasms - therapy Radiotherapy Survival Urology Neoadjuvant chemotherapy Adjuvant chemotherapy Penile cancer Radiotherapy Survival
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Summary:	A multimodal approach to therapy is increasingly used in treating men with advanced penile cancer. Adjuvant chemotherapy improves outcomes in chemotherapy-naïve men with node-positive positive disease, and neoadjuvant chemotherapy can downstage bulky nodal disease sufficiently to permit surgery and has the potential to offer durable long-term survival. However, there remain several unanswered questions in this field, and international collaboration in the form of clinical trials is required to optimize treatment and improve survival in men with advanced penile cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0094-0143 1558-318X
DOI:	10.1016/j.ucl.2016.06.008