Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842

• Published in: Tetrahedron Vol. 67; no. 39; pp. 7540 - 7547
• Main Authors: Kornsakulkarn, Jittra, Dolsophon, Kulvadee, Boonyuen, Nattawut, Boonruangprapa, Tanapong, Rachtawee, Pranee, Prabpai, Samran, Kongsaeree, Palangpon, Thongpanchang, Chawanee
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 30-09-2011; Elsevier
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Bioactive secondary metabolites; Biological and medical sciences; Chemistry; Condensed benzenic and aromatic compounds; Dihydronaphthalenones; Endophytic fungi; Exact sciences and technology; Fungi; Fusarium; Fusarium sp; Mass spectrometry; Medical sciences; Nuclear magnetic resonance; Organic chemistry; Pharmacology. Drug treatments; Preparations and properties; Spectroscopic analysis; Spectroscopy; Tetrahedrons; Bioactive secondary metabolites; Endophytic fungi; UOQVASUKJCBNJL-GABTYQIGSA-N; Dihydronaphthalenones; Fusarium sp; Molecular structure; Metabolite; Cytotoxicity; NMR spectrometry; Biological activity; Fungi; Antifungal agent; Fusarium; Endophyte; Isolation; Fungi Imperfecti; Antibacterial agent; Mass spectrometry; Structural analysis
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2011.07.078

Eleven new dihydronaphthalenones
1–
11, together with five known compounds; 5-hydroxydihydrofusarubin C (
12), javanicin, bostrycoidin, anhydrofusarubin, and 3-
O-methylfusarubin, were isolated from the endophytic fungus
Fusarium sp.
BCC14842. Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3-
O-methylfusarubin, compounds
3 and
7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC
50 of 6.16 μg/mL, while compounds
2,
4,
5,
8, and
12 showed only cytotoxic activity.
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