Glycosides from Wahlenbergia marginata

• Published in: Phytochemistry (Oxford) Vol. 48; no. 7; pp. 1245 - 1250
• Main Authors: Tan, R.X., Ma, W.G., Wei, H.X., Zhang, L.X.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-08-1998; Elsevier
• Subjects: antifungal plants; antifungal properties; Aspergillus flavus; Biological and medical sciences; Campanulaceae; Candida albicans; chemical constituents of plants; Chemical constitution; chemical structure; Fundamental and applied biological sciences. Psychology; General pharmacology; glycosides; Hypocrea rufa; Medical sciences; medicinal plants; nuclear magnetic resonance spectroscopy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant physiology and development; spectral analysis; Asia; China; Wahlenbergia marginata; ionone analogs; wahlenoside A, B and C; demethyl syringin; Campanulaceae; normegastigmane glucoside; glycosides; phenylpropanoid derivatives; Bioassay; Molecular structure; Pharmacognosy; Biological activity; Medicinal plant; Antifungal agent; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Phenols; Isolation; Spermatophyta; Glycoside
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(97)00928-X

Five new glycosides, such as
1 and
2, were isolated from the traditional Chinese medicinal herb
W. marginata (Campanulaceae)
Repeated fractionation of an aqueous ethanol extract of the whole herb of
Wahlenbergia marginata afforded six ionone-related and five phenylpropanoid-derived glycosides. The structures of the five new compounds were established by spectroscopic and chemical methods as 3,5,5-trimethyl-4-(2′-β-D-glucopyranosyloxy)ethyl-cyclohexa-2-en-1-one, demethyl syringin, wahlenosides A, B and C, respectively. All constituents were not active against the human pathogenic fungi
Candida albican, Trichoderma viride and
Aspergillus flavus.