Otolaryngologist’s Encounter With Oncogenic Osteomalacia

A 32-year-old gentleman presented with a 1-year history of multiple atraumatic fractures involving the tibia, fibula, calcaneum, lumbar spine, sacrum, and ribs. On evaluation, he was found to have hypophosphatemia and phosphaturia with normocalcemia and mildly elevated alkaline phosphatase. A low ra...

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Bibliographic Details
Published in:	Ear, nose, & throat journal Vol. 101; no. 1; pp. NP4 - NP5
Main Authors:	Naina, P, Trupthi, M C, Thomas, Nihal, Varghese, Ajoy Mathew
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-01-2022 SAGE PUBLICATIONS, INC
Subjects:	Adult Case reports Endocrine system Humans Male Medical diagnosis Medical Illustration Osteomalacia Otolaryngology Paranasal Sinus Neoplasms Paraneoplastic Syndromes Phosphates Tumors
Online Access:	Get full text
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Summary:	A 32-year-old gentleman presented with a 1-year history of multiple atraumatic fractures involving the tibia, fibula, calcaneum, lumbar spine, sacrum, and ribs. On evaluation, he was found to have hypophosphatemia and phosphaturia with normocalcemia and mildly elevated alkaline phosphatase. A low ratio of maximum rate of renal tubular reabsorption of phosphate to glomerular filtration rate (TMP-GFR: 1.9 mg/100 mL) confirmed renal phosphate wasting. His fibroblast growth factor (FGF 23) was elevated, while his vitamin D and parathyroid hormone levels were normal. Normal urine pH and chloride levels ruled out renal tubular acidosis. Genetic causes of phosphopenic osteomalacia were ruled out by detailed family history. Suspicion of a tumor-induced osteomalacia (TIO) warranted evaluation for any oncogenic cause.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0145-5613 1942-7522
DOI:	10.1177/0145561320936027