Facile approach to diverse 3-acylated indolizines via a sequential Sonogashira coupling/iodocyclization process

Successful implementation of a sequential Pd-catalyzed Sonogashira cross-coupling/iodine-promoted 5-exo-dig cyclization procedure with pyridines bearing a terminal alkyne moiety provided direct and straightforward access to a diverse array of 3-acylated indolizines under mild conditions. [Display om...

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Bibliographic Details
Published in:	Tetrahedron Vol. 68; no. 39; pp. 8198 - 8206
Main Authors:	Jung, Youngeun, Kim, Ikyon
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 30-09-2012 Elsevier
Subjects:	Alkynes Arrays Bearing Chemistry Cross coupling Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Indolizines Iodine-mediated cyclization Joining Organic chemistry Palladium Preparations and properties Pyridines Sonogashira coupling Terminals Tetrahedrons Sonogashira coupling Indolizines Iodine-mediated cyclization Palladium Indolizine derivatives Catalytic reaction Acetylenic compound Mild operating conditions Nitrogen heterocycle Exo stereoisomer Palladium complex Transition metal Pyridine derivatives Pyridine Cyclization Platinoid Acylation Alkyne Iodine
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Summary:	Successful implementation of a sequential Pd-catalyzed Sonogashira cross-coupling/iodine-promoted 5-exo-dig cyclization procedure with pyridines bearing a terminal alkyne moiety provided direct and straightforward access to a diverse array of 3-acylated indolizines under mild conditions. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2012.07.068