Plasma-cell granuloma producing calcitriol and hypercalcemia

A teenage boy presented with hypercalcemia and a large intrathoracic mass. Results of an extensive evaluation, including normal findings on parathyroid hormone and urinary 3', 5'-cyclic adenosine monophosphate assays, failed to explain his hypercalcemia. During surgery, a large plasma-cell...

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Bibliographic Details
Published in:	Annals of internal medicine Vol. 105; no. 3; p. 379
Main Authors:	Helikson, M A, Havey, A D, Zerwekh, J E, Breslau, N A, Gardner, D W
Format:	Journal Article
Language:	English
Published:	United States 01-09-1986
Subjects:	Adolescent Calcitriol - biosynthesis Fibroma - complications Fibroma - metabolism Histoplasmosis - complications Humans Hypercalcemia - etiology Lung Diseases, Fungal - complications Lung Neoplasms - complications Lung Neoplasms - metabolism Male
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Summary:	A teenage boy presented with hypercalcemia and a large intrathoracic mass. Results of an extensive evaluation, including normal findings on parathyroid hormone and urinary 3', 5'-cyclic adenosine monophosphate assays, failed to explain his hypercalcemia. During surgery, a large plasma-cell granuloma of the right middle and lower lobes was resected. Within 2 weeks, serum calcium levels returned to normal. Serum calcitriol (1,25-dihydroxyvitamin D3) levels were elevated before surgery and decreased to normal afterward, correlating with the serum calcium level. Homogenates of the plasma-cell granuloma synthesized a compound indistinguishable from calcitriol.
ISSN:	0003-4819
DOI:	10.7326/0003-4819-105-3-379