Modification of the Electrode Surface by Ag Nanoparticles Decorated Nano Diamond-graphite for Voltammetric Determination of Ceftizoxime

• Published in: Electroanalysis (New York, N.Y.) Vol. 28; no. 3; pp. 469 - 476
• Main Authors: Shahrokhian, Saeed, Ranjbar, Saba, Ghalkhani, Masoumeh
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01-03-2016; WILEY‐VCH Verlag
• Subjects: Atomic force microscopy; Ceftizoxime; Decoration; Diamonds; Electrodes; Modified electrode; Nano diamond-graphite; Nanostructure; Reproducibility; Scanning electron microscopy; Silver; Silver nanoparticle; Voltammetry
• ISSN: 1040-0397; 1521-4109
• DOI: 10.1002/elan.201500377

A modified glassy carbon electrode with a film of nano diamondgraphite nano mixture decorated with Ag nanoparticles (AgNPsNDG/GCE) was constructed and used for sensitive voltammetric determination of ceftizoxime (CFX). Morphology of AgNPsNDG/GCE has been examined by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Experimental variables such as deposited amount of the modifier suspension, pH of the supporting electrolyte and accumulation potential and time were optimized by monitoring of CV and LSV responses of CFX. The results illustrate that AgNPsNDG/GCE exhibits an excellent electrocatalytic effect in the electro‐oxidation of CFX that leads to a considerable improvement in the corresponding anodic peak current. This also allows the development of a highly sensitive voltammetric sensor for the determination of CFX in pharmaceutical and clinical samples. Under the optimum conditions, the modified electrode showed a linear response to the concentration of CFX in the range of 0.02–7 µM with detection limit of 6 nM. The prepared modified electrode has some remarkable electrochemical properties such as simple preparation, high sensitivity, excellent repeatability and reproducibility and long‐term stability.