Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back

Several different tumor types have recently been shown to express functional Fas ligand (FasL), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these findings in the context of potent adversaries such as activated CTL or NK cells remains to be fully...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 158; no. 10; pp. 4521 - 4524
Main Authors:	Walker, P R, Saas, P, Dietrich, P Y
Format:	Journal Article
Language:	English
Published:	United States 15-05-1997
Subjects:	Apoptosis Cytokines - physiology Fas Ligand Protein fas Receptor - physiology Humans Immune Tolerance Immunity, Cellular Ligands Lymphocytes, Tumor-Infiltrating - immunology Membrane Glycoproteins - physiology Neoplasms - immunology T-Lymphocyte Subsets - immunology Tissue Distribution
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Summary:	Several different tumor types have recently been shown to express functional Fas ligand (FasL), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these findings in the context of potent adversaries such as activated CTL or NK cells remains to be fully established. The potential interactions between tumor cells and the host immune response are thus more complex than previously thought; their elucidation will benefit the rational design of cancer immunotherapy strategies.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.158.10.4521