Building blocks for bispecific and trispecific antibodies

Building blocks for bispecific and trispecific antibodies

Bispecific antibodies (BsAbs), which target two antigens or epitopes, incorporate the specificities and properties of two distinct monoclonal antibodies (mAbs) into a single molecule. As such, BsAbs can elicit synergistic activities and provide the capacity for enhanced therapeutic efficacy and/or s...

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Bibliographic Details
Published in:Methods (San Diego, Calif.) Vol. 154; pp. 3 - 9
Main Authors: Wu, Xiufeng, Demarest, Stephen J.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-02-2019
Subjects:
Antibody engineering
Antibody fragments
Bispecific antibodies
Fab-based bispecifics
Fv-based bispecifics
Fv-based bispecifics
Fab-based bispecifics
Antibody engineering
Antibody fragments
Bispecific antibodies
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Description
Summary:Bispecific antibodies (BsAbs), which target two antigens or epitopes, incorporate the specificities and properties of two distinct monoclonal antibodies (mAbs) into a single molecule. As such, BsAbs can elicit synergistic activities and provide the capacity for enhanced therapeutic efficacy and/or safety compared to what can be achieved with conventional monospecific IgGs. There are many building block formats to generate BsAbs and Trispecific antibodies (TsAbs) based on combining the antigen recognition domains of monoclonal antibodies (mAbs). This review describes the many and varied antibody-based building blocks used to achieve multivalency and multispecificity. These diverse building blocks provide opportunities to tailor the design of BsAbs and TsAbs to match the desired applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1046-2023
1095-9130
DOI:10.1016/j.ymeth.2018.08.010