Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate

Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate

Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro- N -(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70–80 °C for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 °C for 7 h to afford th...

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Bibliographic Details
Published in:Fibers and polymers Vol. 21; no. 12; pp. 2718 - 2728
Main Authors: Abdel Bary, Elsayed M., Harmal, Ammar N., Ibrahim, Mona E., Gouda, Moustafa A.
Format: Journal Article
Language:English
Published: Seoul The Korean Fiber Society 01-12-2020
한국섬유공학회
Subjects:
Chemistry
Chemistry and Materials Science
Polymer Sciences
Regular Articles
섬유공학
Deflazacort drug
Mannish base
Drug delivery
Chitosan nanoparticles
Chitosan
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Summary:Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro- N -(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70–80 °C for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 °C for 7 h to afford the corresponding (SCN). These were stirred with Deflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) to give the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be important parameters in controlling the release profiles.
ISSN:1229-9197
1875-0052
DOI:10.1007/s12221-020-0042-2