Modifying role of vitamins on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine

Modifying role of vitamins on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine

Several vitamin compounds have been tested for their ability to suppress the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine, a direct acting mutagen/carcinogen, in Salmonella typhimurium strain TA100. Menadione, alpha-tocopherol, retinal and retinol have displayed high inhibitory activity...

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Bibliographic Details
Published in:Carcinogenesis (New York) Vol. 9; no. 8; p. 1513
Main Authors: Shetty, T K, Francis, A R, Bhattacharya, R K
Format: Journal Article
Language:English
Published: England 01-08-1988
Subjects:
Methylnitronitrosoguanidine - metabolism
Methylnitronitrosoguanidine - toxicity
Mutagens
Vitamins - pharmacology
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Summary:Several vitamin compounds have been tested for their ability to suppress the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine, a direct acting mutagen/carcinogen, in Salmonella typhimurium strain TA100. Menadione, alpha-tocopherol, retinal and retinol have displayed high inhibitory activity. The antimutagenic activity of menadione, in particular, has been found to be remarkable in as much as less than equimolar amount can reduce the mutagenic potency of the carcinogen by 50%. In vitro data suggest that its action is mediated by accelerating the deactivation of the N-nitroso carcinogen, possibly involving the formation of a quinone radical.
ISSN:0143-3334
DOI:10.1093/carcin/9.8.1513