Studies of vitamin A metabolism in mouse model systems

• Published in: BioEssays Vol. 23; no. 5; pp. 409 - 419
• Main Authors: Gottesman, Max E., Quadro, Loredana, Blaner, William S.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01-05-2001
• Subjects: Animals; Intestine, Small - metabolism; Liver - metabolism; Mice; Mice, Knockout; Mice, Transgenic; Pigment Epithelium of Eye - metabolism; Prealbumin - metabolism; Receptors, Retinoic Acid - metabolism; Retinol-Binding Proteins - metabolism; Tretinoin - metabolism; Vitamin A - metabolism
• ISSN: 0265-9247; 1521-1878
• DOI: 10.1002/bies.1059

Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago.1) BioEssays 23:409–419, 2001. © 2001 John Wiley & Sons, Inc.