Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors

• Published in: Genomics (San Diego, Calif.) Vol. 25; no. 2; pp. 388 - 393
• Main Authors: Avraham, Karen B., Fletcher, Colin, Overdier, David G., Clevidence, Derek E., Lai, Eseng, Costa, Robert H., Jenkins, Nancy A., Copeland, Neal G.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 1995; Elsevier
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Crosses, Genetic; DNA-Binding Proteins - genetics; Fundamental and applied biological sciences. Psychology; Genes; Genetics of eukaryotes. Biological and molecular evolution; Hepatocyte Nuclear Factor 3-alpha; Hepatocyte Nuclear Factor 3-beta; Hepatocyte Nuclear Factor 3-gamma; Human; Mice - genetics; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Sequence Data; Muridae - genetics; Nuclear Proteins - genetics; Sequence Alignment; Sequence Homology, Amino Acid; Transcription Factors - classification; Transcription Factors - genetics; Genetic mapping; Vertebrata; Genome organization; Mammalia; Transcription factor HNF3; Gene; Mouse; Rodentia; Chromosome; Multigene family; Transcription factor
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/0888-7543(95)80038-N

A 100-amino-acid DNA-binding motif, known as the winged helix, was first identified in the mammalian hepatocyte nuclear factor-3 (HNF-3) and
Drosophila fork head family of transcription factors. Subsequently, more than 40 different genes that contain the winged helix motif have been identified. In the studies described here, we have determined the murine chromosomal location of eight members of this gene family, HFH-1, HFH-3, HFH-4, HFH-5, HFH-6, HFH-8, BF-1, and BF-2, by interspecific backcross analysis. These genes, designated HNF-3 fork head homolog 1 (
Hfh1),
Hfh3, Hfh4, Hfh5, Hfh6, Hfh8, Hfh9, and
Hfh10, respectively, mapped to 6 different mouse autosomes and are thus well dispersed throughout the mouse genome. Based on this mapping information, we predict the chromosomal location of these genes in humans and discuss the potential of these genes as candidates for uncloned mouse mutations.