Detonation Nanodiamonds as Promising Drug Carriers
Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for...
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Published in: | Pharmaceutical chemistry journal Vol. 54; no. 4; pp. 389 - 403 |
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Abstract | Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the
in vivo
distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence. |
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AbstractList | Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence. Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence. |
Audience | Academic |
Author | Mingalev, P. G. Lisichkin, G. V. Yakovlev, R. Yu Leonidov, N. B. |
Author_xml | – sequence: 1 givenname: R. Yu surname: Yakovlev fullname: Yakovlev, R. Yu organization: V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences – sequence: 2 givenname: P. G. surname: Mingalev fullname: Mingalev, P. G. organization: M. V. Lomonosov Moscow State University – sequence: 3 givenname: N. B. surname: Leonidov fullname: Leonidov, N. B. organization: I. P. Pavlov Ryazan State Medical University, Ministry of Health of the Russian Federation – sequence: 4 givenname: G. V. surname: Lisichkin fullname: Lisichkin, G. V. email: lisich@petrol.chem.msu.ru organization: M. V. Lomonosov Moscow State University |
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CitedBy_id | crossref_primary_10_1007_s13204_020_01568_8 crossref_primary_10_2174_1389201022666210927103755 crossref_primary_10_3390_cells11244029 crossref_primary_10_1016_j_apsusc_2021_149334 crossref_primary_10_1016_j_diamond_2023_109804 |
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SubjectTerms | Drug delivery systems Drug Synthesis Methods and Manufacturing Technology Drugs Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Vehicles |
Title | Detonation Nanodiamonds as Promising Drug Carriers |
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