Detonation Nanodiamonds as Promising Drug Carriers

Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for...

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Published in:Pharmaceutical chemistry journal Vol. 54; no. 4; pp. 389 - 403
Main Authors: Yakovlev, R. Yu, Mingalev, P. G., Leonidov, N. B., Lisichkin, G. V.
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2020
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Abstract Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.
AbstractList Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.
Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the in vivo distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.
Audience Academic
Author Mingalev, P. G.
Lisichkin, G. V.
Yakovlev, R. Yu
Leonidov, N. B.
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  givenname: R. Yu
  surname: Yakovlev
  fullname: Yakovlev, R. Yu
  organization: V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
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  givenname: P. G.
  surname: Mingalev
  fullname: Mingalev, P. G.
  organization: M. V. Lomonosov Moscow State University
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  givenname: N. B.
  surname: Leonidov
  fullname: Leonidov, N. B.
  organization: I. P. Pavlov Ryazan State Medical University, Ministry of Health of the Russian Federation
– sequence: 4
  givenname: G. V.
  surname: Lisichkin
  fullname: Lisichkin, G. V.
  email: lisich@petrol.chem.msu.ru
  organization: M. V. Lomonosov Moscow State University
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Keywords conjugates
drugs
biologically active compounds
nanodiamonds
surface modification
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Snippet Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND...
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crossref
springer
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StartPage 389
SubjectTerms Drug delivery systems
Drug Synthesis Methods and Manufacturing Technology
Drugs
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Vehicles
Title Detonation Nanodiamonds as Promising Drug Carriers
URI https://link.springer.com/article/10.1007/s11094-020-02210-1
Volume 54
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