Detonation Nanodiamonds as Promising Drug Carriers

• Published in: Pharmaceutical chemistry journal Vol. 54; no. 4; pp. 389 - 403
• Main Authors: Yakovlev, R. Yu, Mingalev, P. G., Leonidov, N. B., Lisichkin, G. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2020; Springer
• Subjects: Drug delivery systems; Drug Synthesis Methods and Manufacturing Technology; Drugs; Medicine; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Vehicles; conjugates; drugs; biologically active compounds; nanodiamonds; surface modification
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-020-02210-1

Information on the use of detonation nanodiamonds (DNDs) in biomedical applications is reviewed. Literature data and our own results on the preparation of DND conjugates with biologically active compounds and the
in vivo
distribution of nanodiamonds are presented. The main development directions for designing DND systems to deliver biologically active compounds and drugs are identified. DNDs are attractive for biomedical applications because of their property set that includes biocompatibility, the ability to functionalize the particle surface, strong and specific adsorption/conjugation of drugs and biomolecules, large specific surface area, and stable fluorescence.