TRH test before, during, and after long-term danazol treatment in patients with endometriosis

Ten patients suffering from endometriosis were treated with danazol at a dose of 200 mg three times daily for 6 months. A thyrotropin-releasing hormone (TRH) test was carried out in the follicular phase before treatment, at the sixth month of treatment and after reappearance of the second menses. Th...

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Bibliographic Details
Published in:	Human reproduction (Oxford) Vol. 4; no. 8; p. 903
Main Authors:	Panidis, D K, Matalliotakis, I M, Vayonas, M D, Vlassis, G D, Kalogeropoulos, A P
Format:	Journal Article
Language:	English
Published:	England 01-11-1989
Subjects:	Adult Danazol - therapeutic use Endometriosis - diagnosis Endometriosis - drug therapy Female Follicular Phase Humans Pregnadienes - therapeutic use Thyrotropin - blood Thyrotropin-Releasing Hormone
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Summary:	Ten patients suffering from endometriosis were treated with danazol at a dose of 200 mg three times daily for 6 months. A thyrotropin-releasing hormone (TRH) test was carried out in the follicular phase before treatment, at the sixth month of treatment and after reappearance of the second menses. There was no statistically significant change in the basal level of serum thyroid stimulating hormone (TSH) during danazol treatment. On the contrary, the response of serum TSH in the TRH test was significantly higher during danazol treatment than before or after treatment. Our results support the view that danazol may reduce the secretion of hypothalamic TRH.
ISSN:	0268-1161
DOI:	10.1093/oxfordjournals.humrep.a137008