Studies on thermal, spectral, magnetic and biological properties of new Ni(II), Cu(II) and Zn(II) complexes with a bismacrocyclic ligand bearing an aromatic linker

• Published in: Journal of thermal analysis and calorimetry Vol. 115; no. 3; pp. 2179 - 2189
• Main Authors: Bucur, Cristina, Badea, Mihaela, Chifiriuc, Mariana Carmen, Bleotu, Coralia, Iorgulescu, Emilia Elena, Badea, Irinel Adriana, Grecu, Maria Nicoleta, Lazăr, Veronica, Patriciu, Oana-Irina, Marinescu, Dana, Olar, Rodica
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-03-2014
• Subjects: Analytical Chemistry; Antiinfectives and antibacterials; ANTISEPTICS; BEARINGS; Biological; CALORIMETRY; Chemistry; Chemistry and Materials Science; CHLORIDES; Correlation; ELECTRICAL CONDUCTIVITY; Inorganic Chemistry; LIGANDS; Measurement Science and Instrumentation; Physical Chemistry; Polymer Sciences; Spectra; Tumours; Biofilm; Cytotoxicity; Thermal behaviour; Decaazabismacrocycle; One-pot condensation; Complex
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-013-3460-1

Novel complexes of M
2
LCl
4
·
n
H
2
O type (M:Ni,
n
 = 4; M:Cu,
n
 = 3 and M:Zn,
n
 = 0; L: ligand resulted from 1,4-phenylenediamine, 3,6-diazaoctane-1,8-diamine and formaldehyde one-pot condensation) were synthesized and characterised by microanalytical, ESI–MS, IR, UV–Vis,
1
H NMR and EPR spectra, magnetic data at room temperature and molar conductivities as well. The electrochemical behaviour of complexes was investigated by cyclic voltammetry. Simultaneous TG/DTA measurements were performed in order to evidence the thermal behaviour of the obtained complexes. Processes such as water elimination, fragmentation and oxidative degradation of the organic ligand as well as chloride elimination occurred during thermal decomposition. The antimicrobial assays demonstrate that the compounds exhibited good antibacterial activity, especially against
S. aureus
and
E. coli
strains, the most active being the copper(II) complex, which also exhibited the most prominent anti-biofilm effect, suggesting its potential use for the development of new antimicrobial agents. The biological activity was correlated with log
P
ow
values. All complexes disrupt the membrane integrity of HCT 8 tumour cells.