Maternal and perinatal outcomes of pregnancy associated with COVID-19: Systematic review and meta-analysis

• Published in: European journal of midwifery Vol. 6; no. July; pp. 1 - 22
• Main Authors: Karaçam, Zekiye, Kizilca-Çakaloz, Damla, Güneş-Öztürk, Gizem, Çoban, Ayden
• Format: Journal Article
• Language: English
• Published: European Publishing 06-07-2022
• Subjects: Review Paper
• ISSN: 2585-2906; 2585-2906
• DOI: 10.18332/ejm/149485

INTRODUCTIONThis study explored maternal and infant outcomes in the periods of pregnancy, birth and the postpartum, in women with COVID-19. METHODSAfter PROSPERO registration (CRD42020191106), scanning for the studies was carried out over the period 5-15 May 2020 in the PubMed, Science Direct, EBSCO and Web of Science databases with the search string: ['COVID-19' AND ('pregnancy' OR 'pregnant' OR 'maternal outcomes' OR 'infant outcomes' OR 'fetal outcomes' OR 'birth')]. Studies reporting maternal and perinatal outcomes of pregnant women with COVID-19 were included. Data were extracted independently by two researchers and combined with meta-analysis and pooled analysis. RESULTSThe 54 studies included in this analysis contained data on 517 pregnant women diagnosed with COVID-19 and 385 infants. Of the pregnant women, 18% had gone into preterm labor and 77% had given birth by caesarean. Of the newborns, 19% had low birth weight, 14% had fetal distress, and 24% were admitted into the neonatal intensive care unit. Nine maternal and eight baby mortalities were reported in the studies. CONCLUSIONSThe study revealed that COVID-19 in pregnant women appeared to be negative maternal and infant outcomes, with mortalities as well.