Activity of acid: Co A ligase (AMP) in the course of experimental allergic encephalomyelitis

• Published in: Experimentelle Pathologie Vol. 13; no. 4-5; p. 226
• Main Authors: Wender, M, Zgorzalewicz, B, Talkowska, D
• Format: Journal Article
• Language: English
• Published: Germany 1977
• Subjects: Animals; Coenzyme A Ligases - metabolism; Encephalomyelitis, Autoimmune, Experimental - chemically induced; Encephalomyelitis, Autoimmune, Experimental - enzymology; Encephalomyelitis, Autoimmune, Experimental - metabolism; Encephalomyelitis, Autoimmune, Experimental - pathology; Female; Freund's Adjuvant; Lipid Metabolism; Male; Rats; Staining and Labeling
• ISSN: 0014-4908
• DOI: 10.1016/S0014-4908(77)80006-9

In studies concerned with the activation of fatty acids, a metabolic step initiating the biosynthesis of fatty acids rendering them suitable for elongation, desaturation, esterification or degradation, we have demonstrated that the activity of acid: Co A ligase (AMP) -- E.C.6.2.1.3. is declined throughout the whole investigated period of experimental allergic encephalomyelitis (EAE). This observation clearly indicates that in this experimental disease it is not only the increased catabolism of lipid constituents furnishing the various membraneous structures, including myelin sheats, but also an overall impaired capacity of synthesing new lipids by the diseased cells of the nervous system which must be taken into consideration.