Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles containing varying percentages of folic acid conjugates are characterised, and their biological activity is determined...

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Bibliographic Details
Published in:	RSC advances Vol. 12; no. 54; pp. 35484 - 35493
Main Authors:	Colombo, Eleonora, Coppini, Davide Andrea, Maculan, Simone, Seneci, Pierfausto, Santini, Benedetta, Testa, Filippo, Salvioni, Lucia, Vanacore, Giovanni Maria, Colombo, Miriam, Passarella, Daniele
Format:	Journal Article
Language:	English
Published:	England Royal Society of Chemistry 06-12-2022 The Royal Society of Chemistry
Subjects:	Biological activity Chemistry Conjugates Folic acid Nanoparticles Self-assembly
Online Access:	Get full text
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Summary:	Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles containing varying percentages of folic acid conjugates are characterised, and their biological activity is determined. Self-assembled hetero-nanoparticles are obtained by mixing paclitaxel and folic acid conjugates.
Bibliography:	Electronic supplementary information (ESI) available. See DOI https://doi.org/10.1039/d2ra06306a ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2046-2069 2046-2069
DOI:	10.1039/d2ra06306a