New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp

• Published in: Tetrahedron Vol. 65; no. 5; pp. 1033 - 1039
• Main Authors: Du, Lin, Li, Dehai, Zhu, Tianjiao, Cai, Shengxin, Wang, Fengping, Xiao, Xiang, Gu, Qianqun
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-01-2009; Elsevier
• Subjects: Alicyclic compounds, terpenoids, prostaglandins, steroids; Alkaloid; Chemistry; Deep ocean; Diterpene; Exact sciences and technology; Fungus; Organic chemistry; Penicillium; Penicillium sp; Peptides; Preparations and properties; Terpenoids; Penicillium sp; Diterpene; Fungus; Alkaloid; Deep ocean; Terpenoid; Molecular structure; Penicillium; Cyclic peptides; Mycotoxin; Cytotoxicity; Roquefortine; Stereochemistry; Fungi; Toxin; Cell line; Analog; Dipeptides; Ocean; Fungi Imperfecti; Spectrophotometry; Structural analysis
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2008.11.078

Four new alkaloids, including two new meleagrin analogs, meleagrins B (
2) and C (
3), and two new diketopiperazines, roquefortines F (
5) and G (
6), together with six new diterpenes, conidiogenones B–G (
7–
12), were isolated from a deep ocean sediment derived fungus
Penicillium sp. The structures and stereochemistry of the new compounds were elucidated by spectroscopic methods. The cytotoxicity of the new compounds against the HL-60, A-549, BEL-7402, and MOLT-4 cell lines was evaluated.
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