2-Ylidene-1,3-thiazolidines and their nonhydrogenated analogs: methods of synthesis and chemical properties

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 56; no. 9; pp. 1130 - 1145
• Main Authors: Litvinchuk, Mariia B., Bentya, Anton V., Slyvka, Nataliia Yu, Vovk, Mikhailo V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-09-2020; Springer; Springer Nature B.V
• Subjects: Chemical properties; Chemical synthesis; Chemistry; Chemistry and Materials Science; Organic Chemistry; Pharmacy; 2-ylidene-2,3-dihydro-1,3-thiazoles; functionalization; electrophilic cyclization; 2-ylidene-1,3-thiazolidines; cyclocondensation
• ISSN: 0009-3122; 1573-8353
• DOI: 10.1007/s10593-020-02787-1

The review summarizes and systematizes the literature data on the methods of synthesis and chemical properties of 2-ylidene-1,3-thiazolidines and 2-ylidene-2,3-dihydro-1,3-thiazoles. Two general approaches to their preparation have been identified: the construction of the 2-ylidene-1,3-thiazolidine ring from acyclic precursors in one synthetic process and the introduction of the 2-ylidene fragment into the 1,3-thiazolidine ring. The main chemical transformations of 2-ylidene-1,3-thiazolidines and 2-ylidene-2,3-dihydro-1,3-thiazoles, which include the reactions of selective functionalization and heterocyclization at the ylidene fragment and thiazolidine backbone, are considered. The bibliography of the review consists of 97 references published from 2000 to 2020.