Inhaled Induction and Emergence from Desflurane Anesthesia in the Ambulatory Surgical Patient: The Effect of Premedication

• Published in: Anesthesia and analgesia Vol. 77; no. 3; pp. 540 - 543
• Main Authors: Kelly, Robert E., Hartman, Gregg S., Embree, Patricia B., Sharp, Gloria, Artusio, Joseph E
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01-09-1993; Lippincott
• Subjects: Adult; Ambulatory Surgical Procedures - methods; Anesthesia, Inhalation; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Desflurane; Female; Fentanyl - administration & dosage; Hemodynamics; Humans; Isoflurane - administration & dosage; Isoflurane - adverse effects; Isoflurane - analogs & derivatives; Male; Medical sciences; Midazolam - administration & dosage; Middle Aged; Neuropharmacology; Pharmacology. Drug treatments; Premedication; Volatile compound; Human; Respiratory tract; General anesthetic; Induction; Surgery; General anesthesia; Ambulatory; Irritation; Premedication
• ISSN: 0003-2999; 1526-7598
• DOI: 10.1213/00000539-199309000-00019

We studied the effect of premedication (1 μg/kg fen-tanyl and 0.04 mg/kg midazolam 5 min before induction of anesthesia) on airway reactivity and hemodynamic stability during inhaled induction using desflurane in 10 ambulatory surgical patients. Eight patients who were anesthetized without premedication served as the controls. Induction and emergence were rapid and unaffected by premedication. End-tidal and inspired concentrations of desflurane at loss of consciousness were significantly reduced by premedication (10.1% end-tidal/14.1% inspired, no premedication, vs. 5.3% end-tidal/8.9% inspired, premedication). Airway irritability was markedly attenuated by premedication (100% no premedication versus 30% premedicated), as was apnea (37.5% no premedication versus 0% premedicated). We observed an increase in mean arterial blood pressure and heart rate after loss of consciousness (mean arterial pressure 103 vs 121 mm Hg, heart rate 73 vs 100 bpm) in the unpremedicated patients, whereas both groups demonstrated a decrease in mean arterial blood pressure with no change in heart rate when baseline values were compared to those at incision (103 vs 74 mm Hg, no premedication, 99 vs 81 mm Hg premedicated). Patient acceptability was satisfactory and unchanged by premedication. We recommend the use of such premedication when desflurane is used during the induction of anesthesia.