A Micropatterned Hydrogel Platform for Chemical Synthesis and Biological Analysis

A Micropatterned Hydrogel Platform for Chemical Synthesis and Biological Analysis

A polymer hydrogel platform for peptide arrays compatible both with solid‐phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple‐step peptide synthesis in situ is followed by proof‐of‐concept on‐chip...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) Vol. 18; no. 5; pp. 655 - 659
Main Authors: Zourob, M., Gough, J. E., Ulijn, R. V.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 03-03-2006
WILEY‐VCH Verlag
Subjects:
Arrays
Biosensors
Cells
Enzymes
Hydrogels
Micropatterning
Peptides
Photolithography
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A polymer hydrogel platform for peptide arrays compatible both with solid‐phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple‐step peptide synthesis in situ is followed by proof‐of‐concept on‐chip biological assays involving cells and enzymes (see Figure and cover).
Bibliography:The authors acknowledge VersaMatrix A/S for generous supply of PEGA monomers and the EPSRC for funding through Grant No. GR/T09736/01.
ark:/67375/WNG-HRVQ9P54-C
ArticleID:ADMA200501840
istex:969FA57062BFE81E040CC39F84CBC2D556581682
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200501840