Serodiagnosis of mycoses using recombinant antigens
The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtai...
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| Published in: | Mycopathologia (1975) Vol. 160; no. 2; pp. 97 - 109 |
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01-09-2005
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| Abstract | The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtain, they usually show low reproducibility and are not very specific, since antibodies from patients with different mycoses may show cross-reactivity. The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems. The purpose of this review is to discuss the use of recombinant fungal antigens in the diagnosis of mycoses. |
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| AbstractList | The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtain, they usually show low reproducibility and are not very specific, since antibodies from patients with different mycoses may show cross-reactivity. The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems. The purpose of this review is to discuss the use of recombinant fungal antigens in the diagnosis of mycoses. |
| Author | de Larrinoa, Iñigo Fernández Laín, Ana Pontón, José Lopitz-Otsoa, Fernando Elguezabal, Natalia Moragues, María Dolores |
| Author_xml | – sequence: 1 givenname: Natalia surname: Elguezabal fullname: Elguezabal, Natalia email: oibelven@lg.ehu.es organization: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Vizcaya, Spain. oibelven@lg.ehu.es – sequence: 2 givenname: Fernando surname: Lopitz-Otsoa fullname: Lopitz-Otsoa, Fernando – sequence: 3 givenname: Ana surname: Laín fullname: Laín, Ana – sequence: 4 givenname: Iñigo Fernández surname: de Larrinoa fullname: de Larrinoa, Iñigo Fernández – sequence: 5 givenname: María Dolores surname: Moragues fullname: Moragues, María Dolores – sequence: 6 givenname: José surname: Pontón fullname: Pontón, José |
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| CitedBy_id | crossref_primary_10_1186_1471_2180_7_35 crossref_primary_10_1586_14737159_8_3_315 crossref_primary_10_1155_2008_721950 crossref_primary_10_3389_fgene_2021_777630 crossref_primary_10_5812_pedinfect_81090 crossref_primary_10_1038_s41598_020_60178_0 crossref_primary_10_3923_jbs_2008_760_766 |
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| SubjectTerms | Antibodies Antigens Antigens, Fungal - genetics Bacterial infections Cloning Fungal infections Fungi Fungi - classification Fungi - immunology Humans Mycoses - diagnosis Mycoses - microbiology Recombinant Proteins - genetics Serologic Tests |
| Title | Serodiagnosis of mycoses using recombinant antigens |
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