Serodiagnosis of mycoses using recombinant antigens

The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtai...

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Bibliographic Details
Published in:	Mycopathologia (1975) Vol. 160; no. 2; pp. 97 - 109
Main Authors:	Elguezabal, Natalia, Lopitz-Otsoa, Fernando, Laín, Ana, de Larrinoa, Iñigo Fernández, Moragues, María Dolores, Pontón, José
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01-09-2005
Subjects:	Antibodies Antigens Antigens, Fungal - genetics Bacterial infections Cloning Fungal infections Fungi Fungi - classification Fungi - immunology Humans Mycoses - diagnosis Mycoses - microbiology Recombinant Proteins - genetics Serologic Tests
Online Access:	Get full text
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Summary:	The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtain, they usually show low reproducibility and are not very specific, since antibodies from patients with different mycoses may show cross-reactivity. The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems. The purpose of this review is to discuss the use of recombinant fungal antigens in the diagnosis of mycoses.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0301-486X 1573-0832
DOI:	10.1007/s11046-005-0144-9