Gastric inhibitory polypeptide (GIP) and insulin release in response to oral and intravenous glucose in uremic patients

• Published in: Metabolism, clinical and experimental Vol. 31; no. 11; p. 1096
• Main Authors: Lauritzen, J B, Lauritsen, K B, Olsen, M E, Timmerman, I
• Format: Journal Article
• Language: English
• Published: United States 01-11-1982
• Subjects: Administration, Oral; Adult; Aged; Blood Glucose - analysis; Female; Gastric Inhibitory Polypeptide - blood; Gastrointestinal Hormones - blood; Glucose Tolerance Test; Humans; Infusions, Parenteral; Insulin - metabolism; Insulin Secretion; Male; Middle Aged; Renal Dialysis; Uremia - blood
• ISSN: 0026-0495
• DOI: 10.1016/0026-0495(82)90158-5

Eight patients with advanced renal failure of long duration were studied 1 day after hemodialysis. A 50 g oral glucose load (OGTT) and an intravenous glucose infusion (IVGI), giving the same plasma glucose profile as the OGTT, were carried our in order to study the relation between Gastric Inhibitory Polypeptide (GIP) plasma levels after oral glucose and the insulin release during OGTT and IVGI. The plasma GIP increase during OGTT was significantly elevated compared to a group of eight healthy volunteers. The insulin potentiation during OGTT in relation to GIP was significantly depressed in the uremic patients. It is proposed that a factor of intestinal origin is released during intake of carbohydrates, which blocks the B-cell response to the combined glucose-GIP stimulus. Alternatively, the concentrations of plasma GIp measured have included GIp fragments without insulin releasing capability.