Synthesis and characterization of potential tumor scintigraphic agents

Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99mTc. Three new organometallic compounds, with iminodiacetic acid as the 99mTc chelating group and 2,3-diaminopropionamide as the platinum c...

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Bibliographic Details
Published in:	International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Vol. 38; no. 8; p. 671
Main Authors:	Awaluddin, A B, Jacobs, J J, Bourne, D W, Maddalena, D J, Wilson, J G, Boyd, R E
Format:	Journal Article
Language:	English
Published:	England 1987
Subjects:	Animals Female Humans Indicators and Reagents Mice Mice, Inbred BALB C Neoplasms - diagnostic imaging Osteosarcoma - diagnostic imaging Radionuclide Imaging Structure-Activity Relationship Technetium Tissue Distribution
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Summary:	Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99mTc. Three new organometallic compounds, with iminodiacetic acid as the 99mTc chelating group and 2,3-diaminopropionamide as the platinum complexing group, have been prepared and characterized. Preliminary biodistribution studies in tumor bearing mice support the utility of this approach.
ISSN:	0883-2889
DOI:	10.1016/0883-2889(87)90138-9