Predictors of response to alprazolam and placebo in patients with panic disorder

Date from a panic disorder treatment study with 506 patients, comparing alprazolam and placebo in a double-blind manner for 8 weeks, were analyzed to identify demographic and clinical characteristics of the patients that might predict response to treatment. The strongest predictors of response to al...

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Bibliographic Details
Published in:	Journal of affective disorders Vol. 30; no. 1; p. 5
Main Authors:	Woodman, C L, Noyes, Jr, R, Ballenger, J C, Lydiard, R B, Sievers, G, Mihalko, D
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-1994
Subjects:	Adult Alprazolam - adverse effects Alprazolam - therapeutic use Arousal - drug effects Double-Blind Method Female Humans Male Middle Aged Panic Disorder - drug therapy Panic Disorder - psychology Personality Inventory Social Adjustment
Online Access:	Get more information
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Summary:	Date from a panic disorder treatment study with 506 patients, comparing alprazolam and placebo in a double-blind manner for 8 weeks, were analyzed to identify demographic and clinical characteristics of the patients that might predict response to treatment. The strongest predictors of response to alprazolam were age over 40, and lower baseline levels of anxiety and phobic symptoms. Predictors of response to placebo were weaker and, in addition to lower levels anxiety and panic attacks, included a lack of previous psychiatric treatment.
ISSN:	0165-0327
DOI:	10.1016/0165-0327(94)90146-5