Urinary BTA-stat, BTA-trak and NMP22 in surveillance after TUR of recurrent superficial transitional cell carcinoma of the bladder

• Published in: European urology Vol. 38; no. 4; p. 419
• Main Authors: Serretta, V, Pomara, G, Rizzo, I, Esposito, E
• Format: Journal Article
• Language: English
• Published: Switzerland 01-10-2000
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm - urine; Biomarkers, Tumor - urine; Carcinoma, Transitional Cell - urine; False Positive Reactions; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local - urine; Nuclear Proteins - urine; Predictive Value of Tests; Sensitivity and Specificity; Urinary Bladder Neoplasms - urine
• ISSN: 0302-2838
• DOI: 10.1159/000020318

To evaluate NMP22, BTA-Stat and BTA-Trak tests in monitoring recurrent transitional cell carcinoma of the bladder.
The tests were performed in 179 selected patients being followed up for recurrent superficial bladder tumors: 55 patients had bladder recurrence and 124 patients were recurrence free. The NMP22 test was obtained in all patients; BTA-Stat and BTA-Trak in the last 96 and 74 patients, respectively. Sixty-four patients (51.6%) were undergoing adjuvant intravesical chemotherapy.
Sensitivity was 74, 57 and 62% and specificity was 55, 62 and 79% for NMP22, BTA-Stat and BTA-Trak, respectively. A high percentage of patients submitted to intravesical chemotherapy had false-positive tests. Positive predictive values of the NMP22, BTA-Stat and BTA-Trak tests were 42.2, 40 and 45.4%, and negative predictive values were 82.9, 76.9 and 88.4%, respectively.
NMP22, BTA-Stat and BTA-Trak tests cannot replace cystoscopy and cannot be adopted as routine tools in surveillance after TUR in patients with superficial bladder cancer.