Hydroperoxyeicosatetraenoic acids. Potent inhibitors of lymphocyte responses

Arachidonic acid can be transformed into a series of HPETEs by the lipoxygenase enzyme activity of mouse peritoneal macrophages. These resulting HPETEs inhibit some mouse lymphocyte responses. When mice are injected with 15-L-HPETE, their splenocytes show a decreased [3H]thymidine uptake after lecti...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 750; no. 3; p. 429
Main Authors:	Gualde, N, Chable-Rabinovitch, H, Motta, C, Durand, J, Beneytout, J L, Rigaud, M
Format:	Journal Article
Language:	English
Published:	Netherlands 01-03-1983
Subjects:	Animals Arachidonic Acids - metabolism Arachidonic Acids - pharmacology Female Lectins - pharmacology Leukotrienes Lipid Peroxides Lipoxygenase - metabolism Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - physiology Mice Mice, Inbred C57BL Spleen - drug effects Thymidine - metabolism
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Summary:	Arachidonic acid can be transformed into a series of HPETEs by the lipoxygenase enzyme activity of mouse peritoneal macrophages. These resulting HPETEs inhibit some mouse lymphocyte responses. When mice are injected with 15-L-HPETE, their splenocytes show a decreased [3H]thymidine uptake after lectin stimulation.
ISSN:	0006-3002
DOI:	10.1016/0005-2760(83)90181-9