The inhibition of tail-pinch-induced food intake by cholecystokinin octapeptides and their fragments

• Published in: Life sciences (1973) Vol. 35; no. 2; p. 163
• Main Authors: Telegdy, G, Kádár, T, Kovács, K, Penke, B
• Format: Journal Article
• Language: English
• Published: Netherlands 09-07-1984
• Subjects: Animals; Feeding Behavior - drug effects; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pain; Peptide Fragments - administration & dosage; Peptide Fragments - pharmacology; Rats; Sincalide - administration & dosage; Sincalide - pharmacology
• ISSN: 0024-3205
• DOI: 10.1016/0024-3205(84)90135-8

The effects of intraperitoneally (ip.) and intracerebroventricularly (icv.) administered sulfated and nonsulfated cholecystokinin octapeptide (CCK-8-SE and CCK-8-NS) and their N- and C-terminal fragments on the tail-pinch-induced feeding behavior of rats were investigated. After ip. administration, only CCK-8-SE inhibited tail-pinch-induced food intake. After icv. administration, both CCK-8-SE and CCK-8-NS, in doses of 800 pmole/rat, reduced the amount of food eaten. Of the CCK fragments tested icv., the sulfated N-terminal fragments, the middle portion of the CCK-8-sequence (the CCK-3-6 fragment), and the C-terminal tetrapeptide depressed the food intake of rats during tail-pinch, whereas the C-terminal tripeptide significantly increased it. The results suggest that CCK peptides inhibit tail-pinch-induced feeding by separate mechanisms, depending on the route of administration.