Platelet monoamine oxidase activity and tardive dyskinesia

A few studies of chronic psychiatric inpatients have reported an inverse association between platelet monoamine oxidase (MAO) activity level and tardive dyskinesia (TD). In contrast to these earlier findings, we found no significant or consistent association between platelet MAO activity level and T...

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Bibliographic Details
Published in:	Psychiatry research Vol. 25; no. 2; p. 163
Main Authors:	Morgenstern, H, Hafez, H M, Glazer, W M, Giller, Jr, E, Zahner, G
Format:	Journal Article
Language:	English
Published:	Ireland 01-08-1988
Subjects:	Adult Antipsychotic Agents - adverse effects Bipolar Disorder - drug therapy Bipolar Disorder - enzymology Blood Platelets - enzymology Dyskinesia, Drug-Induced - enzymology Female Humans Male Middle Aged Monoamine Oxidase - blood Psychotic Disorders - drug therapy Psychotic Disorders - enzymology Risk Factors Schizophrenia - drug therapy Schizophrenia - enzymology
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Summary:	A few studies of chronic psychiatric inpatients have reported an inverse association between platelet monoamine oxidase (MAO) activity level and tardive dyskinesia (TD). In contrast to these earlier findings, we found no significant or consistent association between platelet MAO activity level and TD occurrence when we controlled for other TD predictors in a case-control study of 80 outpatients maintained on neuroleptic medications. We did find, however, that black subjects had significantly lower levels of MAO activity than did whites in an analysis controlling for age, sex, and neuroleptic dose.
ISSN:	0165-1781
DOI:	10.1016/0165-1781(88)90047-9