An assessment of sequential measurements of immune complex levels in ovarian cancer patients with respect to clinical progress

• Published in: Gynecologic oncology Vol. 15; no. 2; p. 207
• Main Authors: Mooney, N A, Townsend, P A, Wiltshaw, E, Evans, D G, Shanti-Raju, K, Poulton, T A
• Format: Journal Article
• Language: English
• Published: United States 01-04-1983
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - immunology; Adenocarcinoma - surgery; Adenocarcinoma, Mucinous - drug therapy; Adenocarcinoma, Mucinous - immunology; Adenocarcinoma, Mucinous - surgery; Antigen-Antibody Complex - analysis; Antineoplastic Agents - therapeutic use; Carcinoma, Papillary - drug therapy; Carcinoma, Papillary - immunology; Carcinoma, Papillary - surgery; Endometriosis - drug therapy; Endometriosis - immunology; Endometriosis - surgery; Female; Follow-Up Studies; Humans; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - immunology; Ovarian Neoplasms - surgery
• ISSN: 0090-8258
• DOI: 10.1016/0090-8258(83)90076-8

An evaluation of immune-complex levels as an additional parameter in the clinical follow-up of ovarian cancer patients is described. These patients were treated aggressively with monthly chemotherapy following surgery. Sequential measurements of immune-complex levels have been carried out concurrently and clinical findings were recorded in a uniform manner suitable for comparison with the levels of immune complexes. The relationships between changes in tumor mass and changes in levels of immune complexes were investigated. A significant relationship between decreasing immune-complex levels and simultaneously decreasing tumor mass was found. Chemotherapy was associated with a decrease in immune-complex levels which increased again within 1 month. These data did not support an effective role for immune-complex levels in the evaluation of these patients.