Outcome analysis after post-chemotherapy surgery in patients with non-seminomatous germ cell tumours

• Published in: Annals of oncology Vol. 6; no. 5; p. 483
• Main Authors: Gerl, A, Clemm, C, Schmeller, N, Dienemann, H, Lamerz, R, Kriegmair, M, Wilmanns, W
• Format: Journal Article
• Language: English
• Published: England 01-05-1995
• Subjects: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bleomycin - administration & dosage; Cisplatin - administration & dosage; Combined Modality Therapy; Disease-Free Survival; Etoposide - administration & dosage; Follow-Up Studies; Germinoma - drug therapy; Germinoma - mortality; Germinoma - surgery; Humans; Male; Middle Aged; Survival Rate; Testicular Neoplasms - drug therapy; Testicular Neoplasms - mortality; Testicular Neoplasms - surgery; Treatment Outcome; Vinblastine - administration & dosage
• ISSN: 0923-7534
• DOI: 10.1093/oxfordjournals.annonc.a059219

The goal of the study was to analyse long-term outcome after post-chemotherapy surgery in male patients with non-seminomatous germ cell tumours (NSGCT).
We reviewed the charts of 111 patients with metastatic NSGCT treated at a single institution from 1979 to 1993 who underwent post-chemotherapy resection of residual masses after normalisation of tumour markers. The prognostic relevance of the extent of tumour residuals, the comprehensiveness of surgery and the histology at resection was analysed.
Thirteen patients (12%) harboured viable cancer, and 46 patients (41%) mature teratoma at post-chemotherapy surgery. Only seven (54%) of the 13 patients with viable cancer remained continuously disease-free. Incomplete surgery predicted an impaired outcome (62% vs. 86% survival), although only one recurrence was observed at a site of an incompletely resected mass. Moreover, a progression-free interval < or = 3 months after post-chemotherapy surgery was correlated with worse subsequent survival (p = 0.0001).
Post-chemotherapy surgery remains an essential part of the treatment for metastatic NSGCT. Resection of viable cancer and mature teratoma is of therapeutic benefit. Viable cancer at surgery defines the need for further chemotherapy.