Impedance cardiogram based exploration of cardiac mechanisms in post‐traumatic stress disorder during trauma recall

• Published in: Psychophysiology Vol. 61; no. 4; pp. e14488 - n/a
• Main Authors: Sheikh, Shafa‐at Ali, Shah, Amit J., Bremner, J. Douglas, Vaccarino, Viola, Inan, Omer T., Clifford, Gari D., Rad, Ali Bahrami
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-04-2024
• Subjects: cardiac contractility indices; Congestive heart failure; EKG; Heart failure; impedance cardiogram; Muscle contraction; Post traumatic stress disorder; Risk factors; Sympathetic nervous system; Trauma; trauma recall; heart failure; cardiac contractility indices; impedance cardiogram; trauma recall; Post-traumatic stress disorder
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.14488

Post‐traumatic stress disorder (PTSD) is an independent risk factor for developing heart failure; however, the underlying cardiac mechanisms are still elusive. This study aims to evaluate the real‐time effects of experimentally induced PTSD symptom activation on various cardiac contractility and autonomic measures. We recorded synchronized electrocardiogram and impedance cardiogram from 137 male veterans (17 PTSD, 120 non‐PTSD; 48 twin pairs, 41 unpaired singles) during a laboratory‐based traumatic reminder stressor. To identify the parameters describing the cardiac mechanisms by which trauma reminders can create stress on the heart, we utilized a feature selection mechanism along with a random forest classifier distinguishing PTSD and non‐PTSD. We extracted 99 parameters, including 76 biosignal‐based and 23 sociodemographic, medical history, and psychiatric diagnosis features. A subject/twin‐wise stratified nested cross‐validation procedure was used for parameter tuning and model assessment to identify the important parameters. The identified parameters included biomarkers such as pre‐ejection period, acceleration index, velocity index, Heather index, and several physiology‐agnostic features. These identified parameters during trauma recall suggested a combination of increased sympathetic nervous system (SNS) activity and deteriorated cardiac contractility that may increase the heart failure risk for PTSD. This indicates that the PTSD symptom activation associates with real‐time reductions in several cardiac contractility measures despite SNS activation. This finding may be useful in future cardiac prevention efforts.
This study explores the association between post‐traumatic stress disorder (PTSD) and cardiac pathophysiology in veterans by examining impedance cardiogram‐derived parameters. Employing non‐linear machine learning models for analysis, the study revealed a combination of heightened sympathetic nervous system activity and impaired cardiac contractility in individuals with PTSD during trauma reminders. The findings support our previous research based on linear mixed‐effects model analyses and identify novel biomarkers, providing insight into the physiological impact of PTSD.