Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
Hydroxycarboxylic acid receptor 2 (HCA 2 ) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA 2 may serve as an essential therapeutic target for mediating inflammatio...
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| Published in: | Frontiers in immunology Vol. 12 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Frontiers Media S.A
23-02-2021
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Hydroxycarboxylic acid receptor 2 (HCA
2
) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA
2
may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA
2
, have been reported to play an essential role in maintaining intestinal homeostasis. HCA
2
, predominantly expressed in diverse immune cells, is also present in intestinal epithelial cells (IECs), where it regulates the intricate communication network between diet, microbiota, and immune cells. This review summarizes the physiological role of HCA
2
in intestinal homeostasis and its pathological role in intestinal inflammation and cancer. |
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| Bibliography: | This article was submitted to Nutritional Immunology, a section of the journal Frontiers in Immunology Edited by: Pinyi Lu, Frederick National Laboratory for Cancer Research (NIH), United States Reviewed by: Anastasia N. Vlasova, The Ohio State University, United States; Laura Baldomà, University of Barcelona, Spain |
| ISSN: | 1664-3224 1664-3224 |
| DOI: | 10.3389/fimmu.2021.606384 |