Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case‐cohort study

• Published in: British journal of haematology Vol. 160; no. 6; pp. 838 - 841
• Main Authors: El‐Galaly, Tarec C., Severinsen, Marianne T., Overvad, Kim, Steffensen, Rudi, Vistisen, Anders K., Tjønneland, Anne, Kristensen, Søren R.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-03-2013
• Subjects: Antithrombin III - genetics; Biological and medical sciences; case‐cohort study; Cell Adhesion Molecules - genetics; Cohort Studies; deep venous thrombosis; Denmark; Factor XII - genetics; Fibrin Fibrinogen Degradation Products - genetics; Genetic Predisposition to Disease; Hematologic and hematopoietic diseases; Humans; Medical sciences; Platelet Membrane Glycoproteins - genetics; Polymorphism, Single Nucleotide; pulmonary embolism; Receptors, Cell Surface - genetics; Risk Factors; single nucleotide polymorphism; Tumors; venous thromboembolism; Venous Thrombosis - blood; Venous Thrombosis - genetics; Denmark; Europe; Genetic variability; Hematology; Respiratory disease; Deep vein thrombosis; Cardiovascular disease; Genotype; Venous disease; Vascular disease; Pulmonary embolism; Case study; Cancerology; Blood vessel; Cohort study; venous thromboembolism; Risk factor; case-cohort study; Venous thrombosis; Circulatory system; Single nucleotide polymorphism; Thromboembolism; Vein; deep venous thrombosis
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.12132

Summary
A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.