Modelling of in-vitro and in-vivo performance of aerosol emitted from different vibrating mesh nebulisers in non-invasive ventilation circuit

• Published in: European journal of pharmaceutical sciences Vol. 97; pp. 182 - 191
• Main Authors: Rabea, Hoda, Ali, Ahmed M.A., Salah Eldin, Randa, Abdelrahman, Maha M, Said, Amira S.A., Abdelrahim, Mohamed E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-01-2017
• Subjects: Adult; Aerodynamic characteristics; Aerosols - administration & dosage; Aerosols - pharmacokinetics; Albuterol - administration & dosage; Albuterol - pharmacokinetics; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - pharmacokinetics; Drug Delivery Systems - methods; Female; Humans; Male; Middle Aged; Modelling; Models, Biological; Nebulizers and Vaporizers; Non-invasive ventilation; Noninvasive Ventilation - instrumentation; Noninvasive Ventilation - methods; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - metabolism; Total emitted dose; Vibrating mesh nebulisers; Vibration; Modelling; Non-invasive ventilation; Vibrating mesh nebulisers; Aerodynamic characteristics; Total emitted dose
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/j.ejps.2016.11.018

Substituting nebulisers by another in non-invasive ventilation circuit (NIV) involves many process variables which must be adjusted to ensure patient optimum therapy. However, there is a doubt when nebulisers use the same technology.
Data mining technology based on artificial neural networks and genetic algorithms were used here to model in-vitro inhalation process and predict bioavailability from inhaled doses delivered by three different vibrating mesh nebulisers (VMNs) in NIV.
Modelling of data indicated that in-vitro performance of VMNs was dependent mainly on fine particle fraction, mass median aerodynamic diameter (MMAD), total emitted dose (TED) and to lesser extent on nebuliser type.
Ex-vivo model indicated that amount of salbutamol collected on facemask filter was directly affected by TED. In-vivo model showed that amount of salbutamol deposited into the lung (0.5hQ) and amount absorbed systemically (24hQ) were dependent directly on MMAD and TED. Female patients showed higher 24hQ values than males. Nebuliser type affected TED, 0.5hQ but not 24hQ values.
Results indicate suitability of VMNs in achieving appropriate in-vitro inhalation performance model. The results also, indicate that the three VMNs are comparable and can be interchanged with no fear of any additional toxicity.
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