Body mass index and blood glucose : correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH)

• Published in: Rheumatology international Vol. 26; no. 4; pp. 292 - 297
• Main Authors: DENKO, Charles W, MALEMUD, Charles J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-02-2006; Springer Nature B.V
• Subjects: Age Factors; Biological and medical sciences; Blood Glucose - analysis; Body Mass Index; Diseases of the osteoarticular system; Human Growth Hormone - blood; Humans; Hyperglycemia - blood; Hyperostosis, Diffuse Idiopathic Skeletal - blood; Hyperostosis, Diffuse Idiopathic Skeletal - diagnosis; Insulin; Insulin - blood; Insulin-Like Growth Factor I - analysis; Insulin-like growth factors; Medical sciences; Obesity - blood; Obesity - diagnosis; Diffuse; Human; Diseases of the osteoarticular system; Idiopathic; Rheumatology; Somatotropin hormone; Insulin-like growth factor-1; Glucose; Insulin like growth factor 1; Hyperostosis; Insulin; Blood; Body mass index; Serum; Skeleton; DISH; Bone; Growth hormone
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-005-0588-8

Obesity is a frequent co-morbid condition associated with diffuse idiopathic skeletal hyperostosis (DISH). Serum growth hormone (GH), insulin-like growth factor (IGF-1) and insulin are significantly elevated in patients with DISH. In this study, we examined the relationship between body mass index (BMI) and basal serum GH, IGF-1, and insulin concentration in a group of 36 DISH patients. Basal serum insulin levels were significantly elevated (P<0.001) in DISH patients with a BMI>28 kg m(-2), classified as obese, compared with DISH patients with BMI ranging from 23 to 28 kg m(-2). In addition, BMI strongly positively correlated with serum insulin concentration in DISH patients (adjusted r2 = 0.348, P<0.001). However, BMI did not correlate with either basal serum GH (adjusted r2 = -0.013) or IGF-1 levels (adjusted r2 = -0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH.