The effects of brewers’ spent grain on high-fat diet-induced fatty liver

• Published in: Biochemical and biophysical research communications Vol. 616; pp. 49 - 55
• Main Authors: Pei, Ya, Balogun, Olugbenga, Otieno, Dammah, Parks, John S., Kang, Hye Won
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06-08-2022
• Subjects: Animals; Bile acids; Bile Acids and Salts - metabolism; Brewers' spent grain; Cholesterol; Cholesterol - metabolism; Diet, High-Fat - adverse effects; Hepatic steatosis; Lipid Metabolism - genetics; Liver - metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Obesity - etiology; Obesity - metabolism; Triglycerides - metabolism; Bile acids; Hepatic steatosis; Brewers' spent grain; Cholesterol
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2022.05.056

Obesity drives nonalcoholic fatty liver disease (NAFLD). This study investigated the effects of dietary brewers’ spent grain (BSG) supplementation on obesity-induced NAFLD. Mice fed a high-fat diet supplemented with 30% BSG (HFD30) had reduced body weight and decreased plasma total cholesterol (TC) concentrations compared with HFD-fed mice. Retroperitoneal white adipose tissue (RWAT) and liver weights were reduced. Consistent with reduced hepatic triacylglycerol, TC, and non-esterified fatty acid concentrations, HFD30-fed mice showed reduced hepatic steatosis. 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor genes were increased, whereas carnitine palmitoyltransferase 1 alpha, ATP-binding cassette subfamily A member 1 (Abca1), and cholesterol 7 alpha-hydroxylase genes were upregulated in the liver of HFD30-fed mice. Abca1 gene expression was also increased in epididymal WAT and RWAT of HFD30-fed mice. BSG supplementation increased and decreased fecal fat and bile acid concentrations, respectively. Taken together, BSG supplementation reduced HFD-induced hepatic lipid accumulation by increasing fatty acid oxidation and bile acid synthesis in the liver as well as decreasing lipid absorption in the intestine.
•Brewers' spent grain (BSG) reduces high-fat diet (HFD)-induced weight gain.•BSG alleviates HFD-induced hepatic steatosis.•BSG increases fatty acid oxidation and bile acid synthesis in the liver.•BSG decreases lipid absorption in the intestine.