In Vitro Degradation and Cytotoxicity Evaluation of Iron Biomaterials with Hydroxyapatite Film

• Published in: International journal of electrochemical science Vol. 10; no. 10; pp. 8158 - 8174
• Main Authors: Orinakovà, Renata, Orinak, Andrej, Kupkovà, Miriam, Hrubovcàkovà, Monika, Markusovà-Buckovà, Lucia, Giretovà, Mària, Medvecky, Bubomir, Dobrocka, Edmund, Petrus, Ondrej, Kalavsky, Frantisek
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-10-2015
• Subjects: carbonyl iron; corrosion behaviour; cytotoxicity; electrodeposition; hydroxyapatite; powder metallurgy; hydroxyapatite; powder metallurgy; electrodeposition; cytotoxicity; carbonyl iron; corrosion behaviour
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/S1452-3981(23)11084-4

Biodegradable metallic materials have attracted considerable interest due to their use for temporary medical implants. Coating of metallic implants by bioactive materials like hydroxyapatite (HAp) ceramics is widely used to improve the osteointegration and to ensure the lasting clinical success. The biodegradable iron material was produced by sintering of carbonyl iron powder and coated with electrochemically deposited hydroxyapatite and manganese-doped HAp (MnHAp) ceramics layer. Formation of HAp was proved by XRD analysis. The electrochemical and static immersion corrosion behaviour of developed materials in Hank’s solution was studied. The degradation rate after 13 weeks of immersion as well as the corrosion rate determined from polarisation curves was in the sequence: Fe + HAp, Fe +, Fe, from lower to higher. The moderate negative effect of bioceramic coating on the in vitro cytotoxicity was observed.